Neutrophil: Lymphocyte Ratio and Platelet: Lymphocyte Ratio related to Disease Activity among Rheumatoid Arthritis in Erbil governorate/Iraq

Authors

  • Zekra Aziz Erbil Technical Health and Medical College/ Erbil Polytechnic University
  • Dashty A. Al-Bustany Department of Medicine, College of Medicine, Hawler Medical University

DOI:

https://doi.org/10.25156/ptj.v12n1y2022.pp79-88

Keywords:

Rheumatoid arthritis, Disease activity, Neutrophil , Platelet, Lymphocyte

Abstract

Rheumatoid Arthritis (RA) is a systemic autoimmune inflammatory disorder that causes joints destruction the aim here is to investigate the neutrophil - to -  lymphocyte ratio (NLR)  and  platelet - to- lymphocyte ratio (PLR)  in RA patients and relation to Disease Activity Score of 28 joints (DAS28-ESR).  The study population included (260) participants which consist of (210) RA patients and (50) healthy persons as a control. RA patients were two groups (107) received conventional diseases modified anti-rheumatic drugs (cDMARD) and (103) received biological agents (bDMARD) plus cDMARD each group subdivided into disease active patients (DAS28-ESR ≥ 2.6) and patients in remission (DAS28-ESR < 2.6). NLR in cDMARD, bDMARD plus cDMARD, and control group was 3.1 (±3.4), 2.2 (±1.3), and 2.4 (±1.3) respectively. PLR in cDMARD, bDMARD plus cDMARD, and control group was 193.3 (±355.3), 115.7 (±42.7), and 115.6 (±43.1) respectively. There was statistically significant difference in NLR and PLR among three groups (p = 0.023 and p = 0.030) respectively also according to DAS28-ESR in patients with active disease (p = 0.006)  for both NLR and PLR, while for patients in remission NLR and PLR there were no significant differences detected (p = 0.901 and p = 0.638 respectively). The result of the current study support the idea that NLR and PLR can be considered as inflammatory parameters for evaluating disease activity in RA patients.

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Published

2023-04-16

How to Cite

Aziz, Z., & Dashty A. Al-Bustany. (2023). Neutrophil: Lymphocyte Ratio and Platelet: Lymphocyte Ratio related to Disease Activity among Rheumatoid Arthritis in Erbil governorate/Iraq. Polytechnic Journal, 12(1), 79-88. https://doi.org/10.25156/ptj.v12n1y2022.pp79-88

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Research Articles