Spectrophotometric Determination of Carbamazepine in Pharmaceutical Formulations Based on its Reaction with a Brominating Agent

Authors

DOI:

https://doi.org/10.25156/ptj.v9n2y2019.pp42-49

Keywords:

Bromate-bromide, Carbamazepine;, Cresol red, Methylene blue, Spectrophotometry

Abstract

Two accurate spectrophotometric methods described for the estimation of carbamazepine (CBZ) in both pharmaceutical and pure form. These methodologies are attached to the bromination of CBZ by bromine formed in instantly from the bromate-bromide reaction. The general procedure includes the additional of a known amount of bromate-bromide reagent in an acidic mediocre to CBZ. After the reaction is integrated, the unreacted bromine was reacted with a steady amount of methylene blue, and the absorbance was measured at 665 nm (method A) or, cresol red could be used for the reaction and the absorbance moderated at 517 nm (method B). Beer’s law was submitted from 0.45 to 15.00 ?g/mL CBZ with a molar absorptivity of 4.93 × 103 L/mol.cm for method A and from 0.50 to 12.00 ?g/mL CBZ with a molar absorptivity of 1.37 × 104 L/mol.cm for method B. The proposed methods were effective for the determination of CBZ in tablets with great precision and accuracy.

Downloads

Download data is not yet available.

References

Abdulrahman, S. A. M., K. Basavaiah and H. Doddarevanna. 2010. Use of eco-friendly brominating agent for the spectrophotometric determination of CBZ in pharmaceutical formulations. Malay. 8: 11-24.

Abed, S. S. and M. Q. Al-Abachi. 2015. Spectrophotometric determination of phenylephrine hydrochloride and salbutamol sulphate drugs in pharmaceutical preparations using diazotized metoclopramide hydrochloride. Baghdad Sci. J. 12: 167-177.

Agrawal, Y., R. Giridhar and S. Menon. 1989. Spectrophotometric determination of carbamazepine. Indian J.Pharm. Sci. 51: 75-77.

Anastas, P. T. and J. C. Warner. 1998. Principles of green chemistry. In: Green Chemistry: Theory and Practice. Oxford University Press, New York. p29-56.

Basavaiah, K. and S. A. Abdulrahman. 2014. Utilization of bromination reactions for the determination of carbamazepine using bromate bromide mixture as a green brominating agent. Arabian J. Chem. 7: 297-305.

Çomoğlu, T., N. Gönül, E. Şener, A. Dal and M. Tunçel. 2006. Determination of carbamazapine by flow-injection analysis: Its application to tablet analysis and dissolution studies. J. Liq. Chromatogr. Relat. Technol. 29: 2677-2690.

Demirkaya, F. and Y. Kadioglu. 2005. Determination of carbamazepine using RP-HPLC method in pharmaceutical preparations. FABAD J. Pharm. Sci. 30: 78.

Demirkaya, F. and Y. Kadioglu. 2008. Determination of Carbamazepine in Pharmaceutical Preparations and Pure Forms Using HPLC-DAD, First Order-and Second Order-derivative Spectrophotometric Methods. Proceedings of the International Workshop on New Trends in Science and Technology, Ankara, Turkey.

Džodić, P., L. Živanović, A. Protić, M. Zečević and B. Jocić. 2009. Chemometrically assisted development and validation of LC for simultaneous determination of carbamazepine and its impurities iminostilbene and iminodibenzyl in solid dosage form. Chromatographia. 70: 1343.

Fadhel, S. R., N. I. Abdulla and I. D. Sulaiman. 2017. Spectrophotometric determination of carbamazepine via oxidative coupling reaction with 2, 4-dinitrophenyl hydrazine. Ibn AL-Haitham J. Pure Appl. Sci. 29: 226-238.

Frag, E. Y., M. Zayed, M. Omar, S. E. Elashery and G. G. Mohamed. 2012. Spectrophotometric determination of carbamazepine and mosapride citrate in pure and pharmaceutical preparations. Arab. J. Chem. 5: 375-382.

Huang, C., Q. He and H. Chen. 2002. Flow injection photochemical spectrofluorimetry for the determination of carbamazepine in pharmaceutical preparations. J. Pharm. Biomed. Anal. 30: 59-65.

Index, M., M. O’Neil, P. Heckelman and C. Koch. 2006. The Merck Index. Merck and Co., Whitehouse Station NJ.

Kadioglu, Y. and F. Demirkaya. 2007. Determination of carbamazepine in pharmaceutical dosage form using GC-FID. Chromatographia. 66: 169-172.

Lee, S. H., M. Li and J. K. Suh. 2003. Determination of carbamazepine by chemiluminescence detection using chemically prepared tris (2, 2’-bipyridine) ruthenium (III) as oxidant. Anal. Sci. 19: 903-906.

Liu, F., Y. Wu and B. Zou. 1991. Determination of carbamazepine in tablets by gas chromatography. Sepu.9: 64-65.

Mosher, M. 1992. Organic chemistry. (Morrison, Robert Thornton; Boyd, Robert Neilson). J. Chem. Educ. 69: A305.

Panchagnula, R., K. Kaur, I. Singh and C. Kaul. 1998. Determination of carbamazepine in plasma, urine and formulations by highperformance liquid chromatography. Pharm. Pharmacol. Commun. 4: 401-406

Rao, G. and S. Murty. 1982. Colorimetric determination of carbamazepine in pharmaceutical dosage forms. East. Pharm. 25: 111-112.

Ulu, S. T. 2006. Determination of carbamazepine in pharmaceutical preparations using high-performance liquid chromatography and derivative spectrophotometry. Turk. J. Pharm. Sci. 3: 123-139.

Walker, E. 1988. Liquid chromatographic determination of carbamazepine in tablets. J. Assoc. Official Anal. Chem. 71: 523-525.

Xiong, X. Y., Q. Z. Zhang, F. M. Xiong and Y. H. Tang. 2009. Determination of carbamazepine in pharmaceuticals by flow injection chemiluminescence method. Fenxi Shiyanshi. 28: 56-59.

Yuan, X., H. Jun and J. Mccall. 2003. Determination of carbamazepine in uncoated and film-coated tablets by HPLC with UV detection. Anal. Lett. 36: 1197-1210.

Zhang, Z., S. Chen, W. Huang and F. Xu. 1993. Polarographic determination of carbamazepine in the presence of sodium lauryl sulfate. Yao Xue Xue Bao. 28: 312-316.

Volume 9 Number 2 (2019)

Downloads

Published

2019-12-01

How to Cite

Rizgar, W., & Ali, D. S. (2019). Spectrophotometric Determination of Carbamazepine in Pharmaceutical Formulations Based on its Reaction with a Brominating Agent. Polytechnic Journal, 9(2), 42-49. https://doi.org/10.25156/ptj.v9n2y2019.pp42-49

Issue

Vol. 9 No. 2 (2019)

Section

Research Articles

License

Copyright (c) 2019 Warda Rizgar, Diyar S. Ali

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Authors who publish with this journal agree to the following terms:
1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License [CC BY-NC-ND 4.0] that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this journal.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).