Seroprevalence of Toxoplasma gondii Immunoglobulin G and Immunoglobulin M Antibodies among Leukemia Patients in Erbil City-Kurdistan Region/Iraq by Enzyme-linked Immunosorbent Assay Technique
DOI:
https://doi.org/10.25156/ptj.v11n2y2021.pp1-6Keywords:
Enzyme-linked immunosorbent assay, Immunoglobulin G, Immunoglobulin M, Leukemia, Toxoplasma gondiiAbstract
The current study was revealed the seroprevalence of Toxoplasma gondii immunoglobulin (Ig)G and IgM among different types of leukemia (Acute lymphocytic leukemia, acute myeloid leukemia, Hodgkin lymphoma [HL], multiple myeloma [MM], non-HL [NHL], and chronic myeloid leukemia) from male and female patients in different age groups (18–≥48 years) using indirect enzyme-linked immunosorbent assay. The results of 140 cases of different types of leukemia showed the highest T. gondii IgG (44.44%) among MM leukemia whereas T. gondii IgM highest (12.5%) among NHL leukemia. Significant (P ≤ 0.01) differences between T. gondii antibodies and age group were recorded, that increased with the age of Leukemia patients. Hence, it could be concluded that multiple myeloid leukemia is strong immunocompromised and high significant (P ≤ 0.01) with toxoplasmosis.
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Aburet, D., G. T. Maine, I. Illena, T. Hunt, L. Howard, M. Sheu, S. Brojance, L. E. Chovan, S. F. Nowlan and J. M. Pinon. 2000. Recombinant antigens to detect Toxoplasma gondii-specific immunoglobulin G and immunoglobulin M in human sera by enzyme immunoassay. J. Clin. Microbiol. 38: 1144-1150.
Al-Mukhtar, A. M. and S. M. Al-Najar. 2009. Detection of anti- Toxoplasma antibodies among patients with acute Leukemia or Lymphoma using Latex agglutination and ELISA test. Med. J. Basrah Univ. 27: 95-98.
Aziz, H., C. Y. Ping, H. Alias, N. S. Ab Mutalib and R. Jamal. 2017. Gene mutations as emerging biomarkers and therapeutic targets for relapsed acute myeloid leukemia. Front. Pharmacol. 8: 897.
Bala, R., D. Sharma and A. Kaur. 2016. Acute lymphocytic leukemia diagnosis and treatment-a review. J. Med. Health Sci. 5: 1-7.
Dohner, H., D. J. Weisdorf and C. D. Bloomfield. 2015. Acute myeloid leukemia. N. Engl. J. Med. 373: 1136-1152.
Dubey, J. P. 2010. Toxoplasmosis of Animals and Humans CRC Press is an Imprit of Taylor and Francis Group. United States: CRC Press.
Flegr, J. 2007. Effects of Toxoplasma on human behavior. Schizophr Bull. 33: 757-760.
Gerecke, C., S. Fuhrmann, S. Strifler, M. Schmidt-Hieber, H. Einsele and S. Knop. 2016. The diagnosis and treatment of multiple myeloma. Dtsch Arztebl. Int. 113: 470-476.
Gharavi, M. J., M. Roozbehani and Z. Mandeh. 2017. Detection of anti-Toxoplasma gondii antibodies in chronic myeloid leukemia and acute myeloid leukemia patients. Vet. World. 10: 1063-1065.
Hill, D. and J. P. Dubey. 2002. Toxoplasma gondii: Transmission, diagnosis and prevention. Clin. Microb. Int Fect. 8: 634-640.
Huang, Y., H. Yu, A. Chang, T. Wang, X. Zeng and T. Wu. 2016. Is Toxoplasma gondii infection a risk factor for leukemia? An evidance-based meta-analysis. Med. Sci. Monit. 22: 1547-1552.
Karimi, M., M. Haghighat, Z. Dialameh, L. Tahmasbi, S. Parand and M. Bardestani. 2016. Breast feeding as a protective effect against childhood leukemia and lymphoma. Iran. Red. Crescent Med. J. 18: 29971-29974.
Korbet, S. M. and M. M. Schwartz. 2006. Multiple myeloma. J. Am. Soc. Nephrol. 17: 2533-2545.
Makiani, M. J., P. Davoodian, R. Golsha, M. Dehghani, M. Rajaee and K. Mahoori. 2012. Seroepidemiology and risk factors of toxoplasmosis in the first trimester among pregnant women. Int. Elec. J. Med. 1: 12-17.
Mauz-Körholz, C., M. L. Metzger, K. L. Kelly, C. L. Schwartz, M. E. Castellanos, K. Dieckmann, R. Kluge and D. Körholz. 2015. Pediatric hodgking lymphoma. J. Clin. Oncol. 23: 2975-2989.
Nogai, H., B. Dorken and G. Lenz. 2011. Pathogenesis of nonhodgkin’s lymphoma. J. Oncol. 29: 1803-1811.
Rathee, R., M. Vashist and A. Kumar. 2014. Incidence of acute and chronic forms of leukemia in Haryana. Int. J. Pharm. Pharm. Sci. 6: 323-325.
Tapela, N., I. Nzayisenga, R. Sethi, J. B. Bigirimana, H. Habineza, V. Hategekimana, N. Mantini, T. Mpunga, L. N. Shulman and L. Lehmann. 2016. Teatment of chronic myeloid leukemia in rural Rawanda: Promising early outcomes. J. Global Oncol. 2: 129-137.
Yazar, S., O. Yaman, B. Eser, F. Altuntas, F. Kurnaz and I. Sahin. 2004. Investigation of anti-Toxoplasma gondii antibodies in patients with neoplasia. J. Med. Microbil. 53: 1183-1186.
Yolken, R. H., F. B. Dickerson and T. E. Fuller. 2009. Toxoplasma and schizophrenia. Parasite Immunol. 31: 706-715.
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