Procalcitonin as New Proinflammatory Marker in Burn Patients
DOI:
https://doi.org/10.25156/ptj.v11n1y2021.pp58-62Keywords:
Procalcitonin, Total body surface area, Burn patientAbstract
Procalcitonin (PCT) is a 116 amino acid peptide with a sequence identical to that of prohormone of calcitonin but devoid of hormonal activity. The aim of this study was to determine PCT and it using as a new prognostic pro-inflammatory marker in burn patients and determine the role of PCT level as a mortality indicator in survival and non-survival burn patients. The burn patients in this study were divided into four groups according to the percentage of total body surface area burned carry out on (50) burn patients admitted to the burn unit in West Erbil Emergency Hospital in Erbil governorate and (20) apparently the healthy non-burn individuals who regarded as healthy control group (HC) in this study from February 2012 to April 2012. Out of 50 burnt patients, 20 patients were second sampled to follow-up their immune profile. Regarding PCT there were significant differences (P < 0.05) observed between the mean serum concentration of PCT belong to 18 burn patients of 1st group (G1) (1.24 ± 0.82), 23 patients of 2nd group (G2) (1.52 ± 0.76), six patients of 3rd group (G3) (2. 16 ± 0.11), and three burn patients of 4th group (G4) (6.5 ± 2.87) with mean serum concentration of 18 HC (0.02 ± 0.006). Significant differences obtained when compared to G3 (2.16 ± 0.11) versus G4 (6.5 ± 2.87) using the F-test and t-test. Results show that PCT is a highly productive laboratory parameter involving an easy and rapid beside test for diagnosis and prognosis mortality in burn patients.
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References
Assicot, M., D. Gendrel, H. Carsin, J. Raymond, J. Guilbaud and C. Bohuon. 1993. High serum procalcitonin concentrations in patients with sepsis and infection. Lancet. 341: 515-518.
Dehne, M. G. A. Sablotzki, A. Hoffmann, J. Muhling, F. E. Dietrich and G. Hempelmann. 2002. Alteration of acute phase reaction and cytokine production in patients following severe burn injury. Burn. 28: 535-542.
do Vale, E. C. S. 2005. Initial management of burn. An. Bras. Dermatol. 80(1): 3918.
Enkhbaatar, P. 2004. Pathophysiology of acute lung injury in combined burn and smoke inhalation injury. Clin. Sci. 107(2): 137-143.
Evers, L. H., D. Bhavsar and P. Mailander. 2010. The biology of burn injury. Exp. Dermatol. 19: 777-783.
Hemeda, M., A. Maher and A. Mabrouk. 2003. Epidemiology of burns admitted to Ain Shams University Burns Unit, Cairo, Egypt. Burns. 29(4): 353-358.
Hosseini, R.S., M. Askarian and O. Assadian. 2007. Epidemiology of hospitalized female burn patients in burn center in Sheraz. Eastern Mediterr. Health J. 13(1): 113-118.
Jeschke, M. G., R. P. Mlcak, C. C. Finnerty, W. B. Norbury, G. G. Gauglitz, G. A. Kulp and D. N. Herndon. 2007. Burn size determines the inflammatory and hypermetabolic response. Crit.Care. 11(4): R90.
Keck, M., D. H. Herndon, L. P. Kamolz, M. Frey and M. G. Jeschke. 2009. Pathophysiology of burns. Wiener Med. Wochenschr. 159: 327-336.
Khan, N. and M. A. Malik. 2006. Presentation of burn injuries and their management outcome. J. Pak. Med. Assoc. 56(9): 394-397.
Maghsoudi, H., A. Garadagi, G. A. Jafary, G. Azarmir, N. Aali, B. Karimian and M. Tabrizi. 2005. Women victims of self- nflicted burns in Tabriz, Iran. Burns. 30: 217-220.
McGill, V., A. Kowal-Vern and R. L. Gamelli. 2000. Outcome for older burn patients. Arch. Surg. 135(3): 320-325.
Müller, B., K. L. Becker, H. Schächinger, P. R. Rickenbacher, P. R. Huber, W. Zimmerli and R. Ritz. 2000. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit. Care Med. 28(4): 977-983.
Othman, S. and D. Kendrick. 2010. Epidemiology of burn injuries in the East Mediterranean Region: A systematic review. BMC Public Health. 10: 83.
Pham, T. N., C. B. Kramer, J. Wang, F. P. Rivara, D. M. Heimbach, N. S. Gibran. et al. 2009. Epidemiology and outcomes of older adults with burn injury: An analysis of the national burn repository. J. Burn Care Res. 30: 30-36.
Piccolo, M. T., Y. Wang, P. Sannomiya, N. S. Piccolo, M. S. Piccolo, T. E. Hugli, P. A. Ward and G. O. Till. 1999. Chemotactic mediator requirements in lung injury following skin burns in rats. Exp. Mol. Pathol. 66: 220-226.
Sadeghi-Bazargani, H., R. Mohammadi, L. Svanstrom, R. Ekman, S. Arshi, S. Hekmat, N. Malekpour and M. Mashoufi. 2010. Epidemiology of minor and moderate burns in rural Ardabil, Iran. Burns. 36(6): 933-937.
Sheridan, R. L. 2000. Evaluating and managing burn wounds. Dermatol. Nurs. 12(1): 17-18.
Siamanga, H. 2002. Burn injuries treatment of burn patients prior to admission to the emergency department. Ann. Burns Fire Disasters. 15(2): 53-58.
Singh, V., L. Devgan, S. Bhat and S. M. Milner. 2007. The pathogenesis of burn wound conversion. Ann. Plast. Surg. 59: 109-115.
Sterner, J. B. 2009. Inflammatory mediators in smoke inhalation injury. Inflamm. Allergy Drug Target. 8: 63-69.
Taghaddosinejad, F., A. Sheikhazadi, B. Behnoush, J. Reshadati and S. H. Sabery. 2010. A survey of suicide by burning in Tehran, Iran. Acta Med. Iran. 48(4): 266-272.
Taghavi, M., M. R. Rasouli, N. Boddouhi, M. R. Zarei, A. Khaji and M. Abdollahi. 2010. Epidemiology of outpatient burns in Tehran: An analysis of 4813 cases. Burns. 36(1): 109-113.
ul-Muqim, R., Z. Mohammad, Dilbag, H. Muhammad and M. I. Khan. 2007. Epidemiology and outcome of burns at Khyber teaching hospital Peshawar. Pak. J. Med. Sci. 23(3): 420-424.
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