Vitamin D Deficiency is Associated with Anemia, Cardiovascular Risk, and Lifestyle
DOI:
https://doi.org/10.25156/ptj.v11n1y2021.pp134-138Keywords:
Vitamin D deficiency, Anemia, Lifestyle, HematologyAbstract
Traditionally, Vitamin D has been associated primarily with bone health, while further investigations revealed that a sufficient amount is important for many organ functions. Data of 314 individuals were obtained from Erbil governorate public and private hospitals from patients admitted to there for testing their level of Vitamin D and other tests according to their doctor’s prescription. The variable related to their lifestyle, metabolic syndrome, and hematology evaluations were obtained. The body mass index , number of sleeping hours, number of hours spent with electronic devices, serum lipid level anemia-related tests were measured. The results showed that serum 25(OH) Vitamin D levels in studied individuals were related to hyperlipidemia serum cholesterol measures. The level of Vitamin B12 and Iron status were lower in the Vitamin D deficiency (VDD) individuals. Mean platelet volume was higher in vitamin-deficient patients which induces the risk of cardiovascular (CV) diseases. This finding suggests the relation between VDD and metabolic syndrome, CV, and anemia-related measurement.
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Al-Sumaih, I., Johnston, B., Donnelly, M. and O’neill, C. 2020. The relationship between obesity, diabetes, hypertension and vitamin D deficiency among Saudi Arabians aged 15 and over: results from the Saudi health interview survey. BMC Endocr. Disord. 20(1): 81.
Anglin, R.E., Samaan, Z., Walter, S.D. and Mcdonald, S.D. 2013. Vitamin D deficiency and depression in adults: Systematic review and meta-analysis. Br. J. Psychiatr. 202: 100-107.
Atkinson, M.A., Melamed, M.L., Kumar, J., Roy, C.N., Miller, E.R. 3rd., Furth, S.L. and Fadrowski, J.J. 2014. Vitamin D, race, and risk for anemia in children. J. Pediatr. 164(1): 153-158. e1.
Bell, N.H., Epstein, S., Greene, A., Shary, J., Oexmann, M.J. and Shaw, S. 1985. Evidence for alteration of the vitamin D-endocrine system in obese subjects. J. Clin. Investig. 76(1): 370-373.
Calvo, M.S., Whiting, S.J. and Barton, C.N. 2005. Vitamin D intake: A global perspective of current status. J. Nutr. 135(2): 310-316.
Culha, M.G., Atalay, H.A., Canat, H.L., Alkan, I., Ozbir, S., Can, O. and Otunctemur, A. 2018. The relationship between erectile dysfunction severity, mean platelet volume and Vitamin D levels. Aging Male. 23(3): 173-178.
Golbahar, J., Altayab, D., Carreon, E. and Darwish, A. 2013. Association of Vitamin D deficiency and hyperparathyroidism with anemia: A cross-sectional study. J. Blood Med. 4: 123.
Hirani, V., Cumming, R.G., Blyth, F., Naganathan, V., Le Couteur, D.G., Waite, L.M., Handelsman, D.J. and Seibel, M.J. 2015. Cross-sectional and longitudinal associations between the active Vitamin D metabolite (1, 25 dihydroxyvitamin D) and haemoglobin levels in older Australian men: The concord health and ageing in men project. Age. 37(1): 8.
Holick, M.F. 2007. Vitamin D deficiency. N. Engl. J. Med. 357(3): 266-281.
Jaumdally, R.J., Varma, C., Blann, A.D., Macfadyen, R.J. and Lip, G.Y. 2007. Platelet activation in coronary artery disease: Intracardiac vs peripheral venous levels and the effects of angioplasty. Chest. 132(5): 1532-1539.
Lee, J.A., Hwang, J.S., Hwang, I.T., Kim, D.H., Seo, J.H. and Lim, J.S. 2015. Low Vitamin D levels are associated with both iron deficiency and anemia in children and adolescents. Pediatr. Hematol. Oncol. 32(2): 99-108.
Mergl, R., Dogan-Sander, E., Willenberg, A., Wirkner, K., Kratzsch, J., Riedel-Heller, S., Allgaier, A.K., Hegerl, U. and Sander, C. 2021. The effect of depressive symptomatology on the association of Vitamin D and sleep. BMC Psychiatry. 21(1): 1-10.
Mete, T., Yalcin, Y., Berker, D., Ciftci, B., Guven, S., Topaloglu, O., Yavuz, H. and Guler, S. 2013. Obstructive sleep apnea syndrome and its association with Vitamin D deficiency. J. Endocrinol. Investig. 36(9): 681-685.
Nur-Eke, R. and Özen, M. 2020. The relationship between Vitamin D levels and iron deficiency and anemia in adults applied for periodic medical examination. Clin. Lab. 66(6): 1019-1026.
Oren, Y., Shapira, Y., Agmon-Levin, N., Kivity, S., Zafrir, Y., Altman, A., Lerner, A. and Shoenfeld, Y. 2010. Vitamin D insufficiency in a sunny environment: A demographic and seasonal analysis. Israel Med. Assoc. J. 12(12): 751.
Parikh, S.J., Edelman, M., Uwaifo, G.I., Freedman, R.J., Semega- Janneh, M., Reynolds, J. and Yanovski, J.A. 2004. The relationship between obesity and serum 1, 25-dihydroxy Vitamin D concentrations in healthy adults. J. Clin. Endocrinol. Metab. 89(3): 1196-1199.
Pereira-Santos, M., Costa, P.R.D., Assis, A.M.O., Santos, C.A.D. and Santos, D.B.D. 2015. Obesity and Vitamin D deficiency: A systematic review and meta-analysis. Obes. Rev. 16(4): 341- 349.
Pourshahidi, L.K. 2015. Vitamin D and obesity: Current perspectives and future directions. Proc. Nutr. Soc. 74(2): 115-124.
Riccio, E., Sabbatini, M., Bruzzese, D., Capuano, I., Migliaccio, S., Andreucci, M. and Pisani, A. 2015. Effect of paricalcitol vs calcitriol on hemoglobin levels in chronic kidney disease patients: A randomized trial. PLoS One. 10(3): e0118174.
Rondina, M.T., Weyrich, A.S. and Zimmerman, G.A. 2013. Platelets as cellular effectors of inflammation in vascular diseases. Circ. Res. 112(11): 1506-1519.
Santoro, D., Caccamo, D., Lucisano, S., Buemi, M., Sebekova, K., Teta, D. and De Nicola, L. 2015. Interplay of Vitamin D, erythropoiesis, and the renin-angiotensin system. Biomed Res. Int. 2015;2015:145828.
Semple, J.W. and Freedman, J. 2010. Platelets and innate immunity. Cell. Mol. Life Sci. 67(4): 499-511.
Sim, J.J., Lac, P.T., Liu, I.L.A., Meguerditchian, S.O., Kumar, V.A., Kujubu, D.A. and Rasgon, S.A. 2010. Vitamin D deficiency and anemia: A cross-sectional study. Ann. Hematol. 89(5): 447-452.
Sooragonda, B., Bhadada, S.K., Shah, V.N., Malhotra, P., Ahluwalia, J. and Sachdeva, N. 2015. Effect of Vitamin D replacement on hemoglobin concentration in subjects with concurrent irondeficiency anemia and Vitamin D deficiency: A randomized, single-blinded, placebo-controlled trial. Acta Haematol. 133(1): 31-35.
Valettas, N. and Herrmann, H.C. 2003. The role of platelets and platelet inhibition in acute myocardial infarction. Coron. Artery Dis. 14(5): 357-363.
Wang, Y., Andrews, M., Yang, Y., Lang, S., Jin, J., Cameron- Vendrig, A., Zhu, G., Reheman, A. and Ni, H. 2012. Platelets in thrombosis and hemostasis: Old topic with new mechanisms. Cardiovasc. Haematol. Disord. Drug Targets. 12(2): 126-132.
Wortsman, J., Matsuoka, L.Y., Chen, T.C., Lu, Z. and Holick, M.F. 2000. Decreased bioavailability of Vitamin D in obesity. Am. J. Clin. Nutr. 72(3): 690-693.
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Copyright (c) 2021 Hawro D. Ismael, Goran Q. Othman, Azad H. Amin, Jabbar H. Odey, Badraddin O. Abdulla Gardy, Hashm H. Abdullah, Layla A. Kareem, Hataw J. Taher
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