Nephroprotective Role of L-Cysteine, Silymarin and Ursodeoxycholic acid, against Carbon Tetrachloride induced Oxidative Stress in Male Albino Rats

Authors

  • Hero Helal Muhammed Saed Chemistry Department, College of Education, University of Garmian, Kalar, Kurdistan Region, Iraq
  • Zeyan Abdullah Ali Salahaddin
  • Sarwar N. Jafar Biology Department, College of Education, University of Salahaddin, Erbil, Kurdistan Region, Iraq
  • Treefa F. Ismail Biology Department, College of Education, University of Salahaddin, Erbil, Kurdistan Region, Iraq

DOI:

https://doi.org/10.25156/ptj.v13i1.783

Keywords:

L-cysteine, Silymarin, CCl4, Kidney, Oxidative stress, Rats

Abstract

The comparison of histopathological and biochemical effects of L-cysteine, silymarin and ursodeoxycholic acid which have a protective effect on kidney function against CCl4 induce nephrotoxicity were investigated in this study. Twenty adult male rats were divided into 5 groups and treated as follows, the control group was administrated 1.5 ml/kg. B.W physiological solution (0.9%) orally, Carbon Tetrachloride group (CCl4 1.5 ml/kg. B.W), L-cysteine (100mg/kg B.W.) +CCl4 group, ursodeoxycholic acid (50 ml/kg B.W.) +CCl4 group, and the last group was Silymarin 100 mg/kg. B.W with CCl4, the experiment lasted 30 days. Oxidative stress caused by CCl4 caused increasing in Creatinine and Urea levels in serum while decreasing the level of uric acid and albumin when compared with the control group, L-cysteine, Silymarin and the drug presented ameliorating effect by decreasing creatinine, Urea, and increasing the level of uric acid with albumin. Histopathological results showed that CCl4 caused oxidative damage in kidney tubules in comparison with control group, while Silymarin, L-cysteine showed nephroprotective effects.

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References

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Published

2023-09-20

How to Cite

Helal Muhammed Saed, H., Abdullah Ali, Z., N. Jafar, S. ., & F. Ismail, T. . (2023). Nephroprotective Role of L-Cysteine, Silymarin and Ursodeoxycholic acid, against Carbon Tetrachloride induced Oxidative Stress in Male Albino Rats . Polytechnic Journal, 13(1), 109-115. https://doi.org/10.25156/ptj.v13i1.783

Issue

Vol. 13 No. 1 (2023)

Section

Research Articles

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Copyright (c) 2023 Zeyan Abdullah Ali

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